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KMID : 0356620080230040253
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Journal of Korean Society of Endocrinology
2008 Volume.23 No. 4 p.253 ~ p.259
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Determinants of the Brachial-Ankle Pulse Wave Velocity (baPWV) in Patients with Type 2 Diabetes Mellitus
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Lee Seong-Woo
Lee Chang-Won
Yun Kyung-Won
Kim Bo-Hyun
Yu Yun-Sik
Lim Hong-Kyu
Bae Young-Pil
Yi Byeong-Do
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Abstract
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Background: Pulse wave velocity (PWV) correlates with arterial distensibility and stiffness and is a useful
method for evaluating the severity of systemic atherosclerosis in adults. Brachial-ankle PWV (baPWV) is
affected by many different factors such as age, systolic blood pressure (SBP), sex, body mass index, waist to
hip ratio, and HbA1c. We evaluated the determinants of baPWV in patients with type 2 diabetes mellitus.
Methods: The study included 803 type 2 diabetic patients over age 30 who had their ankle brachial
pressure index (ABI) and baPWV measured at Busan St. Mary’s Medical Center, Busan, Korea.
Anthropometric parameters, blood pressure, pulse pressure, fasting plasma glucose, fasting insulin, HbA1c, lipid
profile, high sensitivity C-reactive protein (hs-CRP), and microalbuminuria were checked concurrently. We also
investigated tobacco and alcohol use by means of questionnaire. We then retrospectively analyzed the
relationships between baPWV and various risk factors.
Results: Differences between men and women were measured using the independence sample probate.
Pearson correlation analysis confirmed the factors affecting the baPWV as follows: SBP, diastolic blood
pressure, pulse pressure, age, waist circumference, gender, and duration of diabetes mellitus were positively
correlated, and height and weight were negatively correlated. On aged-adjusted partial correlation, HbA1c, SBP,
diastolic blood pressure, and pulse pressure were correlated. By multiple linear regression analysis, SBP, age,
HbA1c, and weight were independent predictors of baPWV.
Conclusion: The baPWV is principally affected by SBP and age in patients with type 2 diabetes mellitus.
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KEYWORD
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atherosclerosis, pulse wave velocity, type 2 diabetes mellitus
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